After their first development in the middle Mesozoic, the overall NW-SE striking border fault systems of the Roer Valley Graben were reactivated as reverse faults under Late Cretaceous compression (inversion) and reactivated again as normal faults under Cenozoic extension. In Flanders (northern Belgium), a new geological model was created for the western border fault system of the Roer Valley Graben. After carefully evaluating the new geological model, this study shows the presence of two structural domains in this fault system with distinctly different strain distributions during both Late Cretaceous compression and Cenozoic extension. A southern domain is characterized by narrow (< 3 km) localized faulting, while the northern is characterized by wide (> 10 km) distributed faulting. The total normal and reverse throw in the two domains was estimated to be similar during both tectonic phases. The repeated similarities in strain distribution during both compression and extension stresses the importance of inherited structural domains on the inversion/rifting kinematics besides more obvious factors such as stress directions. The faults in both domains strike NW-SE, but the change in geometry between them takes place across the oblique WNW-ESE striking Grote Brogel fault. Also in other parts of the Roer Valley Graben, WNW-ESE striking faults are associated with major geometrical changes (left-stepping patterns) in its border fault system. This study thereby demonstrates the presence of different long-lived structural domains in the Roer Valley Graben, each having their particular strain distributions that are related to the presence of non-colinear faults.