Heat flux heterogeneities at the bottom of Earth's mantle play an important role in the dynamic of the underlying core. Here, we study how these heterogeneities are affected by the global rotation of the Earth, called true polar wander (TPW), which has to be considered to relate mantle dynamics with core dynamics. We find that TPW can greatly modify the large scales of heat flux heterogeneities, notably at short timescales. We provide representative maps of these heterogeneities.