This study achieved high-precision hypocenters of 335 earthquakes (1–4.2 M_L) and 1D velocity models of the Southern and Eastern Alps. The general pattern of seismicity reflects head-on convergence of the Adriatic Indenter with the Alpine orogenic crust. The relatively deeper seismicity in the eastern Southern Alps and Giudicarie Belt indicates southward propagation of the Southern Alpine deformation front. The derived hypocenters form excellent data for further seismological studies, e.g., LET.