High-resolution 3D reflection seismic data from the Orange Basin, South Africa, are used to provide an in-depth examination of features within the Late Cretaceous to Cenozoic sedimentary successions. The study provides insight into the structural styles between the translational and compressional domains of a Late Cretaceous deep-water fold-and-thrust belt (DWFTB) system, together with the tectonic and oceanographic processes responsible for mass-scale erosion in the Cenozoic.