We postulate that the observed spatial distribution of large earthquakes in active convergence zones, organised in segments where large events are repeated every 100–300 years, depends on large-scale continental faults and fluid release from the subducting slab. In order to support this model, we use proxies at different spatial and temporal scales (historic seismicity, megathrust slip solutions, inter-seismic cumulative seismicity, GPS/viscous plate coupling, and coastline morphology).