Several cross-hole seismic surveys in the undisturbed Rotondo granite are used to analyze the seismic anisotropy in the Bedretto Lab, Switzerland. The P and S1 waves show a clear trend of faster velocities in the NE–SW direction and slower velocities perpendicular to it, indicating a tilted transverse isotropic velocity model. The symmetry plane is mostly aligned with the direction of maximum stress, but also the orientation of fractures is expected to influence the velocities.