We address the transition between the Paleozoic Variscan and Alpine Mesozoic–Cenozoic cycles using tectono-stratigraphy and thermochronology. This transition unfolds through a multi-phase rifting history. An initial rifting stage occurred in the early Permian, followed in the early–middle Permian by a phase of transcurrent tectonics. This was succeeded by a period of erosion/non-deposition in the middle Permian. Crustal stretching in the Middle Triassic marked the onset of the Alpine cycle.